Check the attachment about "Honda HDS user guide.pdf"

FLY100 VS HDS:

FLY100 uses USB2.0, HDS use COM port
HDS need password when program keys, FLY100 doesn’t need it
HDS cannot do odometer correction, FLY100 can do odometer correction without removing the cluster
FLY100 provides free training
FLY100 provides free technical support
FLY100 provides free updates
HDS cannot work for new Guangdong
HONDAFLY100 can do airbag reset
HDS cannot do adaptation for remote controller, FLY100 can do it
HDS cannot make smart key, FLY100 can make it.

HDS vs Fly100 vs Fly108 vs Fly200 vs GNA600:

Similarities:

Car type: all work with Honda cars.
Test system coverage: Cover all the electronic control system.
Hardware and software requirements:
PC / Laptop: Windows 2000 Professional (SP4 or later) or XP (SP1 or later).
Hard disk drive with at least 400MB of free space
CD-ROM drive (if a high-speed Internet connection is not available)
RS232 port required to connect PC to HIM (PC version software only)
Monitor capable of displaying in VGA mode or above (1024 x 768 recommended)
Internet connection (high-speed connection recommended)
Update:all updated by CD.

Differences:

Difference in supported car model
HDS: only work with Honda
Fly100: work with Honda and Acura
Fly108: work with Honda, Ford and Mazda
Fly200: work with Ford, Mazda
GNA600: work with Honda and Acura vehicle

Difference in function
Fly100 locksmith version only support make key, not support diagnosis. While the other onese can both make key and diagnose.

Tips:
Better to install the software on the computer with Windows XP system.
Better to close the Anti-virus software on your computer. Because the Anti-virus may recognise it as a type of virus, it will clear off all the software on the CD.